After receiving a Licentiate in Business administration, Archimandrite Prof. Jack Khalil joined the St John of Damascus Institute of Theology – University of Balamand, from where he received a Bachelor of Theology degree in 1998. In the same year, he began his postgraduate studies in the exegesis of the New Testament at the Aristotle University of Thessalonica Theological School, and from 1999 till 2002 he followed courses and seminars as Visiting Fellow at the Eberhard-Karls-Universität, in Tübingen, Germany.

His doctoral thesis, defended at the Aristotle University – Thessaloniki (2003), deals with the soteriological teaching of St Paul, examining mainly the doctrine of Justification and Reconciliation by faith in relation to the Last Judgment. It has been admitted as a textbook reference at the University of Thessaloniki since 2005. He has been Lecturer in Biblical exegesis at Balamand University - Lebanon (2000-2004), then Assistant Professor (2005) then Associate Professor (2011). Furthermore, he has been visiting Professor in many Orthodox Theological Faculties and Institutes over the world, e.g. University of Thessaloniki, IOCS (Cambridge) and St. Serge (Paris), University of Eastern Finland (Joensuu). He is the author of one book published in Greek by Pournaras Publishers - Thessalonica, and many researches and studies published in Lebanon, Greece, France, USA, Belgium, Estonia, and Bulgaria.

Archimandrite Jack Khalil is a member of the Biblical Federation in Lebanon and the Middle East, the Hellenic Society of Biblical Studies, the Revision Committee of the van-Dyck–Boustani Bible Arabic Translation, and he was also the Orthodox representative in the WCC Continuation Committee on “Ecumenism in the 21st Century” that met 5 times between 2007 and 2012. He is a member of the  World Council of Churches Central Committee, and a member of the commission "Faith and Order". He represented the Patriarchate of Antioch and All the East in the Committee of the Eastern Orthodox and Oriental Orthodox Churches for the Collaboration with the United Bible Societies. He is an ordained priest of the Orthodox Church (Patriarchate of Antioch) and holds the clerical rank of Archimandrite.